Reacción #1889992

Ecuación de reacción

Ethyl 7-nitroindole-2-carboxylate

lithium hydroxide hydrate

hydrochloric acid

→

7-nitro-1H-indole-2-carboxylic acid

Disolventes

tetrahydrofuran

water

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONwas added
2. 2
   ExtracciónThe mixture was extracted with ethyl acetate
3. 3
   SecadoThe extract was dried over anhydrous magnesium sulfate
4. 4
   Filtraciónfiltered
5. 5
   workup.DISTILLATIONThe filtrate was distilled under reduced pressure

Procedimiento

Ethyl 7-nitroindole-2-carboxylate (500 mg, 2.14 mmol) was dissolved in a solvent mixture of tetrahydrofuran and water (1:1, 20 ml), and lithium hydroxide hydrate (448 mg, 10.7 mmol) was added. The mixture was stirred for 8 h at room temperature, and 1N-hydrochloric acid solution was added thereto. The mixture was extracted with ethyl acetate. The extract was dried over anhydrous magnesium sulfate and filtered. The filtrate was distilled under reduced pressure to give 7-nitro-1H-indole-2-carboxylic acid.

Fuente