Reacción #1889

Ecuación de reacción

2-amino-5-chloro-α-(2-chlorophenyl)benzyl alcohol

trifluoroacetic acid

sodium hydrogen carbonate

→

crystal

Rendimiento 95.7%

5-chloro-α-(2-chlorophenyl)-2-(trifluoroacetylamino)benzyl alcohol

Rendimiento 95.7%

Disolventes

dichloromethane

dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroAfter reaction
2. 2
   Otrothe organic layer was dried
3. 3
   Otroafter which the solvent was removed
4. 4
   Otrothe residue was recrystallized from hexane

Procedimiento

To a solution of 1.0 g of 2-amino-5-chloro-α-(2-chlorophenyl)benzyl alcohol in 12 ml of dichloromethane, a solution of 0.8 g of anhydrous trifluoroacetic acid in 2 ml of dichloromethane was added. After reaction, an aqueous solution of sodium hydrogen carbonate was added, and the organic layer was dried, after which the solvent was removed and the residue was recrystallized from hexane to yield 1.3 g of a crystal.

Fuente