Reacción #1887

Ecuación de reacción

sodium cyanoborohydride

2-amino-5-chloro-α-(2,4,6-trimethoxyphenyl)benzyl alcohol

trimethylacetaldehyde

acetic acid

→

crystal

5-chloro-α-(2,4,6-trimethoxyphenyl)-2-(neopentylamino)benzyl alcohol

Disolventes

ethanol

Condiciones de reacción

Tratamiento posterior

1. 1
   ConcentraciónAfter concentration and subsequent dilution with water
2. 2
   Extracciónthe solution was extracted with ethyl acetate
3. 3
   OtroAfter solvent removal

Procedimiento

After a solution of 2.5 g of 2-amino-5-chloro-α-(2,4,6-trimethoxyphenyl)benzyl alcohol, 1.01 ml of trimethylacetaldehyde and 0.56 g of acetic acid in 30 ml of ethanol was stirred at room temperature for 1.5 hours, 0.81 g of sodium cyanoborohydride was added, followed by stirring overnight. After concentration and subsequent dilution with water, the solution was extracted with ethyl acetate. After solvent removal, the residue was subjected to silica gel column chromatography to yield 2.2 g of a crystal.

Fuente