Reacción #1886

Ecuación de reacción

water

2-amino-5-chloro-2',4',6'-trimethoxybenzophenone

lithium aluminum hydride

→

crystal

Rendimiento 96.1%

2-amino-5-chloro-α-(2,4,6-trimethoxyphenyl)benzyl alcohol

Rendimiento 96.1%

Disolventes

tetrahydrofuran

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónthe solution was extracted with ethyl acetate
2. 2
   Secadodried over anhydrous sodium sulfate
3. 3
   Otroafter which the solvent was removed

Procedimiento

To a solution of 3.0 g of 2-amino-5-chloro-2',4',6'-trimethoxybenzophenone in 50 ml of tetrahydrofuran, 0.43 g of lithium aluminum hydride was added, followed by stirring for 1 hour. After water was added, the solution was extracted with ethyl acetate and dried over anhydrous sodium sulfate, after which the solvent was removed and the residue was subjected to silica gel column chromatography to yield 2.9 g of a crystal.

Fuente