Reacción #1885001

Ecuación de reacción

4-propylphenylboric acid

1-bromo-3-chloro-5-fluorobenzene

sodium carbonate

toluene ethanol water

→

4-propyl-1-(3-chloro-5-fluorophenyl)benzene

Rendimiento 97.7%

Disolventes

toluene

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturathe mixture was refluxed for 5 hours
2. 2
   Lavadowashed with 1N hydrochloric acid and water
3. 3
   SecadoThen, the resulting solution was dried over magnesium sulfate
4. 4
   workup.DISTILLATIONdistilled under reduced pressure
5. 5
   Otroto remove the solvent
6. 6
   OtroThe residue was purified by silica-gel column chromatography with heptane as eluent
7. 7
   Otrodried under reduced pressure

Procedimiento

At first, 25.8 g of 4-propylphenylboric acid (S1-1), 30.0 g of 1-bromo-3-chloro-5-fluorobenzene (S1-2), 2.5 g of tetrakis(triphenylphosphine)palladium, 50.1 g of sodium carbonate and 700 ml of a mixed solvent of toluene/ethanol/water=3/3/1 (volume ratio) were added into a reactor under nitrogen atmosphere, and then the mixture was refluxed for 5 hours. Next, the reaction solution was cooled to room temperature, added with toluene and then washed with 1N hydrochloric acid and water. Then, the resulting solution was dried over magnesium sulfate and then distilled under reduced pressure to remove the solvent. The residue was purified by silica-gel column chromatography with heptane as eluent and then dried under reduced pressure to obtain 34.8 g of 4-propyl-1-(3-chloro-5-fluorophenyl)benzene (S1-3). The yield of the compound (S1-3) from (S1-1) was 97.7%.

Fuente