Reacción #1884995

Ecuación de reacción

3,4-di-fluoro-benzaldehyde

malonic acid

piperidine

pyridine

HCl

→

3,4-di-fluoro-cinnamic acid

Rendimiento 95.0%

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaAfter heating it to 80° C.
2. 2
   workup.STIRRINGthe mixture was stirred for 12 hours
3. 3
   OtroAfter the reaction
4. 4
   Temperaturathe resulting solution cooled down to room temperature
5. 5
   FiltraciónThe resulting powder was filtered
6. 6
   Lavadowashed with water
7. 7
   Otrodried in a vacuum oven

Procedimiento

10 g (70.4 mmol) of 3,4-di-fluoro-benzaldehyde, 14.65 g (2 eq.) of malonic acid, and 0.59 g (0.1 eq.) of piperidine were added to 16.7 g (3 eq.) of pyridine and stirred at room temperature for about 1 hour. After heating it to 80° C., the mixture was stirred for 12 hours. After the reaction, the resulting solution cooled down to room temperature and was slowly added with 1M HCl until it was titrated to about pH 4. The resulting powder was filtered and washed with water, and then dried in a vacuum oven. (Yield: 95%)

Fuente