Reacción #1882290

Ecuación de reacción

2-methylbenzoic acid

EDCl

dimethylhydroxylamine hydrochloride

→

N-methoxy-N,2-dimethylbenzamide

Rendimiento 80.0%

Disolventes

DMA

DCM

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónThe reaction mixture is then filtered
2. 2
   workup.ADDITIONThe filtrate is diluted with EtOAc
3. 3
   Lavadowashed with water, 10% NaHSO4 and brine
4. 4
   SecadoThe solution is dried over Na2SO4
5. 5
   Otrothe solvent is evaporated

Procedimiento

To a premixed solution of 2-methylbenzoic acid (7.5 mmol), EDCl (1.5 mmol) and DMAP (3.0 mmol) in DMA 40 mL and DCM 13 mL is added dimethylhydroxylamine hydrochloride (1.5 mmol). The reaction is stirred at room temperate over night. The reaction mixture is then filtered. The filtrate is diluted with EtOAc and washed with water, 10% NaHSO4 and brine. The solution is dried over Na2SO4 and the solvent is evaporated. A light yellow oil N-methoxy-N,2-dimethylbenzamide is obtained in 80% yield.

Fuente