Reacción #1876812

Ecuación de reacción

Bromine

Compound ( b )

3-ethoxybenzotrifluoride

Water

→

Compound ( c )

Rendimiento 76.9%

2-bromo-5-ethoxybenzotrifluoride

Rendimiento 76.9%

Disolventes

ether

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónthe aqueous layer was extracted three times with ether
2. 2
   Lavadowashed with saturated aqueous sodium bicarbonate and water
3. 3
   Secadodried over anhydrous magnesium sulfate
4. 4
   workup.DISTILLATIONThe solvent was distilled off under reduced pressure

Procedimiento

Bromine (18.2 g) was slowly added dropwise to Compound (b) (19.3 g) at room temperature, and then the mixture was stirred at room temperature for 1 hour. Water and ether were added for liquid separation, and the aqueous layer was extracted three times with ether. The organic layers were combined, washed with saturated aqueous sodium bicarbonate and water, and then dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to obtain 21.0 g of Compound (c).

Fuente