Reacción #1876811

Ecuación de reacción

Potassium carbonate

methyl ethyl ketone

ethyl iodide

MEK

3-trifluoromethylphenol

→

Compound ( b )

3-ethoxybenzotrifluoride

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturathe reaction mixture was heated
2. 2
   Otroto room temperature
3. 3
   Extracciónthe aqueous layer was extracted three times with diethyl ether
4. 4
   Lavadowashed with an 1 M aqueous sodium hydroxide solution
5. 5
   Secadodried over anhydrous magnesium sulfate
6. 6
   workup.DISTILLATIONThe solvent was distilled off under reduced pressure

Procedimiento

Potassium carbonate (22.6 g) and then a mixture of methyl ethyl ketone (MEK) (150 mL) and ethyl iodide (47.8 g) were added to a mixture of MEK (310 mL) and 3-trifluoromethylphenol (a) (25.0 g) at room temperature, and the reaction mixture was heated and stirred for 2 hours. After returning the mixture to room temperature, water was added for liquid separation and the aqueous layer was extracted three times with diethyl ether. The organic layers were combined, washed with an 1 M aqueous sodium hydroxide solution and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to obtain 19.3 g of Compound (b).

Fuente