Reacción #1869218

Ecuación de reacción

Water

Salicylaldehyde

(2S)-oxiran-2-ylmethyl 3-nitrobenzenesulfonate

Cs2CO3

→

subtitle compound

Rendimiento 114.8%

2-[(2S)-oxiran-2-ylmethoxy]benzaldehyde

Rendimiento 114.8%

Disolventes

DMF

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónthe mixture was extracted with DCM (2×50 ml)
2. 2
   LavadoThe combined organic extracts were washed with water (2×50 ml)
3. 3
   OtroThe volatiles were removed in vacuo

Procedimiento

Salicylaldehyde (486 mg, 3.99 mmol) and (2S)-oxiran-2-ylmethyl 3-nitrobenzenesulfonate (900 mg, 3.47 mmol) was dissolved in DMF (5 ml) and Cs2CO3 (1.28 g, 3.94 mmol) was added. The reaction mixture stirred for 12 at room temperature. Water (100 ml) was added, and the mixture was extracted with DCM (2×50 ml). The combined organic extracts were washed with water (2×50 ml). The volatiles were removed in vacuo to give the subtitle compound (76%, 710 mg), which was used directly in the next step.

Fuente