Reacción #1869217

Ecuación de reacción

AlCl3

4-tert-butyl-2-methoxybenzenesulfonyl chloride

pyrrolidine

→

subtitle compound

Rendimiento 53.3%

2-(pyrrolidin-1-ylsulfonyl)phenol

Rendimiento 53.3%

Disolventes

xylene

DMF

Condiciones de reacción

Tratamiento posterior

1. 1
   Concentraciónconcentrated in vacuo
2. 2
   workup.DISSOLUTIONThe residue was dissolved in xylene (10 ml)
3. 3
   workup.STIRRINGThe resulting mixture was stirred for 18 h at 70° C
4. 4
   workup.ADDITIONwas poured
5. 5
   workup.STIRRINGinto stirred ice-cold water
6. 6
   Extracciónextracted with ether (2×30 ml)
7. 7
   SecadoThe ether layer was dried over sodium sulfate
8. 8
   Filtraciónfiltered
9. 9
   Concentraciónconcentrated

Procedimiento

To a solution of 4-tert-butyl-2-methoxybenzenesulfonyl chloride (258 mg, 0.99 mmol) in DMF (6 ml) was added pyrrolidine (70 mg, 0.99 mmol) and the solution was stirred at ambient temperature for 30 minutes, and concentrated in vacuo. The residue was dissolved in xylene (10 ml) and then added to mixture of AlCl3 (525 mg, 3.39 mmol) in xylene (5 ml). The resulting mixture was stirred for 18 h at 70° C. After colling the mixture was poured into stirred ice-cold water, and extracted with ether (2×30 ml). The ether layer was dried over sodium sulfate, filtered and concentrated to give 120 mg of subtitle compound.

Fuente