Reacción #1869212

Ecuación de reacción

ethyl acetate

(2,4-dimethoxyphenyl)acetic acid

N,N-carbonyldiimidazole

methyl amine

→

subtitled compound

Rendimiento 73.3%

2-(2,4-Dimethoxyphenyl)-N-methylacetamide

Rendimiento 73.3%

Disolventes

DMF

H2O

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.STIRRINGthe reaction mixture was stirred at room temperature over the week-end
2. 2
   SecadoThe organic layer was dried over Na2SO4
3. 3
   Filtraciónfiltered
4. 4
   Concentraciónconcentrated
5. 5
   OtroThe residue was purified by silica gel flash chromatography (0-80% ethyl acetate in petroleum spirit)

Procedimiento

A mixture of (2,4-dimethoxyphenyl)acetic acid (577 mg, 3.0 mmol) and N,N-carbonyldiimidazole (608 mg, 3.75 mmol) in DMF (10 mL) was stirred at room temperature for 45 min, aqueous 40% methyl amine (4.5 mL) was added and the reaction mixture was stirred at room temperature over the week-end. The reaction mixture was is partitoned between ethyl acetate and H2O. The organic layer was dried over Na2SO4, filtered and concentrated. The residue was purified by silica gel flash chromatography (0-80% ethyl acetate in petroleum spirit) to give the subtitled compound (460 mg).

Fuente