Reacción #1869201

Ecuación de reacción

chloroquinolone

DMF

phosphorus tribromide

sodium carbonate

→

solid

10-Bromo-9-chloro-2,3-dihydro-[1,4]dioxino[2,3-f]quinoline

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturacooling for 30 minutes
2. 2
   workup.STIRRINGstirred for a further 2 hours
3. 3
   TemperaturaIt was cooled in ice
4. 4
   Otrothe solid was collected
5. 5
   Lavadowashed well with water
6. 6
   Otrodried in vacuo

Procedimiento

The chloroquinolone (7a) in dry DMF (8 mL) was cooled in ice and phosphorus tribromide (0.7 mL) added drop-wise, and the mixture was stirred, with ice-cooling for 30 minutes then allowed to warm to room temperature and stirred for a further 2 hours. It was cooled in ice and sodium carbonate solution was added and the solid was collected, washed well with water, and dried in vacuo, to afford a pale yellow solid (1.65 g).

Fuente