Reacción #1869194

Ecuación de reacción

2-chloro-8-benzyloxyquinoline

NaOMe

→

oil

Rendimiento 92.0%

8-Benzyloxy-2-methoxyquinoline

Rendimiento 92.0%

Disolventes

toluene

MeOH

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe reaction solution was heated
2. 2
   TemperaturaAfter cooling to room temperature
3. 3
   workup.ADDITIONthe reaction solution was poured onto ice
4. 4
   Extracciónextracted with toluene
5. 5
   SecadoThe combined organic extracts were dried (MgSO4)
6. 6
   Concentraciónconcentrated in vacuo

Procedimiento

The crude 2-chloro-8-benzyloxyquinoline from above was dissolved in toluene (10 mL) and added to a stirred 25 wt % solution of NaOMe in MeOH (50 mL). The reaction solution was heated with stirring overnight at 70° C. After cooling to room temperature, the reaction solution was poured onto ice and extracted with toluene. The combined organic extracts were dried (MgSO4) and concentrated in vacuo to give a colorless oil (6.14 g, 92%). The product was used without further purification.

Fuente