Reacción #1869192

Ecuación de reacción

hydroxypyridine

2-Bromo-5-hydroxy-6-nitropyridine

potassium carbonate

Et2O

→

material

Rendimiento 89.0%

Ethyl (6-bromo-2-nitro-pyridin-3-yloxy)acetate

Rendimiento 89.0%

Disolventes

acetone

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe reaction was heated
2. 2
   Temperaturaat reflux for 10 hours
3. 3
   OtroThe precipitate was removed by suction filtration
4. 4
   Concentraciónthe filtrate was concentrated in vacuo

Procedimiento

The hydroxypyridine (f) (30 g, 0.14 mol) was suspended in acetone (200 ml), and potassium carbonate (39 g, 0.28 mol) was added, followed by ethyl bromoacetate (15.7 ml, 0.14 mmol). The reaction was heated at reflux for 10 hours, then was cooled to room temperature and diluted with Et2O. The precipitate was removed by suction filtration, and the filtrate was concentrated in vacuo to afford material (38 g, 89%), which was used without further purification.

Fuente