Reacción #1869188

Ecuación de reacción

( b )

4-Oxo-1,4-dihydro-quinoline-6-carbonitrile

phosphorous tribromide

→

product

Rendimiento 87.0%

4-Bromo-quinoline-6-carbonitrile

Rendimiento 87.0%

Disolventes

—

ice water

DMF

water

Condiciones de reacción

Tratamiento posterior

1. 1
   FiltraciónThe product was filtered off
2. 2
   Lavadowashed with water and air
3. 3
   Otrodried

Procedimiento

To a solution of (b) (12 g, 70.5 mmol) in DMF (75 ml) was added dropwise phosphorous tribromide (8 ml, 84.6 mmol) over five minutes (slightly exothermic). The reaction was allowed to cool to room temperature and was then diluted with ice water (100 ml) and stirred 1 hour then diluted with additional water (300 ml). The product was filtered off, washed with water and air dried to provide 14.3 g of product (87%).

Fuente