Reacción #1869187

Ecuación de reacción

Intermediate ( a )

4-[(2,2-Dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidenemethyl)-amino]-benzonitrile

Dowtherm A

→

gold

Rendimiento 94.3%

4-Oxo-1,4-dihydro-quinoline-6-carbonitrile

Rendimiento 94.3%

Disolventes

ether

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaAfter an additional five minutes at reflux
2. 2
   FiltraciónThe product was filtered off
3. 3
   Lavadothoroughly washed with ether
4. 4
   Otroair dried

Procedimiento

Intermediate (a) (27.5 g, 0.101 mol) was slowly added over five minutes to refluxing Dowtherm A (200 ml). After an additional five minutes at reflux, the mixture was allow to cool to room temperature then ether (200 ml) was added. The product was filtered off, thoroughly washed with ether then air dried to afford the product as a gold coloured solid (16.2 g, 94%).

Fuente