Reacción #1862448

Ecuación de reacción

2-amino-4-trifluromethylbenzamide

4-chloro-2-ethylsulfanylbenzaldehyde

sodium bisulfite

sodium bicarbonate

→

2-(4-chloro-2-ethylsulfanylphenyl)-7-trifluoromethyl-3H-quinazolin-4-one

Rendimiento 80.7%

Disolventes

DMA

water

Condiciones de reacción

Tratamiento posterior

1. 1
   Filtraciónthe precipitated solid was filtered
2. 2
   LavadoThe resulting solid was washed with water and n-hexane
3. 3
   Otrodried

Procedimiento

A mixture of 1.0 g of 2-amino-4-trifluromethylbenzamide, 944 mg of 4-chloro-2-ethylsulfanylbenzaldehyde, 765 mg of sodium bisulfite and 4 ml of DMA was stirred at 150° C. for 15 hours. A saturated aqueous sodium bicarbonate solution and water were added to the cooled reaction mixture, and the precipitated solid was filtered. The resulting solid was washed with water and n-hexane and then dried to obtain 1.46 g of 2-(4-chloro-2-ethylsulfanylphenyl)-7-trifluoromethyl-3H-quinazolin-4-one.

Fuente