Reacción #1857547

Ecuación de reacción

dichloro methane

sodium hydride

2-[2-chloro-4-(4-chlorophenoxy)phenyl]-1-(1,2,4-triazol-1-yl)but-3-en-2-ol

methyl iodide

→

desired compound

1-[2-[2-chloro-4-(4-chlorophenoxy)phenyl]-2-methoxy-but-3-enyl]-1,2,4-triazole

Disolventes

Brine

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaThe mixture was then heated for 10 h
2. 2
   Temperaturato reflux
3. 3
   Otrothe organic phase was dried
4. 4
   Otroevaporated
5. 5
   Otroto obtain the crude product
6. 6
   OtroThis was purified by column chromatography

Procedimiento

2-[2-chloro-4-(4-chlorophenoxy)phenyl]-1-(1,2,4-triazol-1-yl)but-3-en-2-ol (0.4 g) was dissolved in THF (10 mL) and sodium hydride (0.03 g) was added. The mixture was stirred for 30 min at room temperature and methyl iodide (0.08 mL) was added. The mixture was then heated for 10 h to reflux. Brine and dichloro methane were added, the organic phase was dried and evaporated to obtain the crude product. This was purified by column chromatography to obtain 0.04 g of the desired compound.

Fuente