Reacción #1857541

Ecuación de reacción

4-chlorophenol

2-chloro-4-fluoroacetophenone

potassium carbonate

→

1-[2-chloro-4-(4-chlorophenoxy)phenyl]ethanone

Disolventes

DMF

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturawas heated
2. 2
   Temperaturato reflux for 48 h
3. 3
   Otrothe reaction mixture was partitioned between MTBE and water
4. 4
   Extracciónthe aqueous phase was extracted twice with MTBE
5. 5
   LavadoThe combined organic phases were consecutively washed with 10% LiCl solution, dil. NaOH solution and water
6. 6
   Otrodried
7. 7
   OtroThe solvent was evaporated under reduced pressure
8. 8
   Otrothe crude material was crystallized from diisopropyl ether

Procedimiento

A mixture of 4-chlorophenol (186 g), 2-chloro-4-fluoroacetophenone (250 g) and potassium carbonate (238 g) in DMF (960 mL) was heated to reflux for 48 h. After cooling to room temperature, the reaction mixture was partitioned between MTBE and water and the aqueous phase was extracted twice with MTBE. The combined organic phases were consecutively washed with 10% LiCl solution, dil. NaOH solution and water and dried. The solvent was evaporated under reduced pressure and the crude material was crystallized from diisopropyl ether.

Fuente