Reacción #1852177

Ecuación de reacción

sodium thiosulfate

1-hexine-3-ol

5-iodo-2,3,4-trifluoro-1-[trans-4-(trans-4-propylcyclohexyl)cyclohexyl]benzene

→

5-(3-hydroxy-1-hexynyl)-2,3,4-trifluoro-1-[trans-4-(trans-4-propylcyclohexyl)cyclohexyl]benzene

Rendimiento 85.5%

Disolventes

DMF

triethylamine

DMF

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONwere added
2. 2
   workup.ADDITIONwas added dropwise for 20 minutes
3. 3
   workup.STIRRINGstirred for a while
4. 4
   Otroan organic layer was separated
5. 5
   Extracciónan aqueous layer was extracted with toluene
6. 6
   ExtracciónAfter the extract
7. 7
   workup.ADDITIONthe organic layer were mixed together
8. 8
   Lavadowashed
9. 9
   Secadowater, a saturated sodium hydrogen carbonate aqueous solution, and a saturated saline solution in that order, and dried
10. 10
    Otrothe solvent was evaporated under a reduced pressure
11. 11
    OtroThe residue was purified

Procedimiento

In a nitrogen atmosphere, 25 g of 5-iodo-2,3,4-trifluoro-1-[trans-4-(trans-4-propylcyclohexyl)cyclohexyl]benzene was dissolved into 300 mL of DMF, to which 21 mL of triethylamine, 0.19 g of copper iodide (I), and 0.58 g of tetrakistriphenylphosphine palladium (0) were added, followed by heating to 55° C. Into this, the DMF (30 mL) solution containing 5.9 g of 1-hexine-3-ol was added dropwise for 20 minutes, and stirred for 3 hours. After the reaction mixture was poured into a sodium thiosulfate aqueous solution, and stirred for a while, an organic layer was separated and an aqueous layer was extracted with toluene. After the extract and the organic layer were mixed together, washed using water, 10% hydrochloric acid twice, water, a saturated sodium hydrogen carbonate aqueous solution, and a saturated saline solution in that order, and dried using anhydrous magnesium sulfate, the solvent was evaporated under a reduced pressure. The residue was purified by sequentially carrying out column chromatography (silica gel, toluene) twice, activated carbon treatment (acetone), and column chromatography (silica gel, hexane/acetone), to obtain 20 g of 5-(3-hydroxy-1-hexynyl)-2,3,4-trifluoro-1-[trans-4-(trans-4-propylcyclohexyl)cyclohexyl]benzene.

Fuente