Reacción #1847720

ord-156b5646cd3b40188857c28bbd8d31cc

Ecuación de reacción

CC(C)c1cc(Cl)nc(-c2ccc(Cl)cc2)n1
4-chloro-2-(4-chlorophenyl)-6-isopropylpyrimidine
C1COCCN1
morpholine
CC(C)c1cc(N2CCOCC2)nc(-c2ccc(Cl)cc2)n1
2-(4-Chlorophenyl)-6-isopropyl-4-morpholinopyrimidine

Disolventes

Condiciones de reacción

Temperatura
130°CELSIUS
Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    TemperaturaAfter cooling
  2. 2
    Filtraciónthe solid was filtered off with suction
  3. 3
    Otrodried at 50° C. in vacuo

Procedimiento

A mixture of 267 mg of 4-chloro-2-(4-chlorophenyl)-6-isopropylpyrimidine and 522 mg of morpholine was heated at 130° C. for 2 hours. After cooling, 20 ml of water were added, the mixture was stirred, and the solid was filtered off with suction and dried at 50° C. in vacuo. Yield: 0.28 g.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US06844347B1uspto-grants-2005_01