Reacción #1847719

Ecuación de reacción

4-chloro-2-(4-chlorophenyl)-6-isopropylpyrimidine

4-amino-2,2,6,6-tetramethylpiperidine

→

2-(4-Chlorophenyl)-6isopropyl-4-((2,2,6,6-tetramethylpiperidin-4-yl)amino)-pyrimidine dihydrochloride

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   TemperaturaAfter cooling
2. 2
   workup.STIRRINGthe mixture was stirred at room temperature
3. 3
   FiltraciónThe white precipitate was filtered off with suction
4. 4
   Otrodried in vacuo
5. 5
   workup.ADDITIONBy addition of hydrogen chloride
6. 6
   Otrothe title compound was precipitated
7. 7
   Filtraciónfiltered off with suction
8. 8
   Otrodried in vacuo

Procedimiento

A mixture of 534 mg of 4-chloro-2-(4-chlorophenyl)-6-isopropylpyrimidine and 1.8 g of 4-amino-2,2,6,6-tetramethylpiperidine was heated at 150° C. for 2 hours with stirring. After cooling, 20 ml of water were added and the mixture was stirred at room temperature. The white precipitate was filtered off with suction, dried in vacuo and taken up in 20 ml of ethyl acetate. By addition of hydrogen chloride, the title compound was precipitated, filtered off with suction and dried in vacuo. Yield: 0.8 g.

Fuente