Reacción #1846

Ecuación de reacción

4-bromoanisole

Magnesium

iodine

THF

1,2-dibromoethane

→

Anisylmagnesium Bromide

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaat reflux for 15 min
2. 2
   workup.STIRRINGstirring
3. 3
   OtroAfter an exothermic reaction
4. 4
   workup.STIRRINGstirring
5. 5
   Otrowas accompanied by a rise in temperature to 35° C
6. 6
   TemperaturaThe mixture was cooled to 20° C.
7. 7
   Temperaturawith cooling
8. 8
   workup.STIRRINGStirring
9. 9
   workup.ADDITIONafter the addition

Procedimiento

Magnesium (36 g, 1.5 mol), iodine (a few crystals) and THF (1 L) were heated under nitrogen, with stirring, at reflux for 15 min. The mixture was cooled to 20° C., stirring stopped, and 1,2-dibromoethane (2.5 ml) added. After an exothermic reaction was observed (a few min) stirring was restarted which was accompanied by a rise in temperature to 35° C. The mixture was cooled to 20° C. and 4-bromoanisole slowly added over 1 h at 14°-18° C. with cooling. Stirring was continued for 10 min after the addition was complete.

Fuente