Reacción #1841

Ecuación de reacción

phenol

potassium carbonate

5-fluoro-2-nitrotoluene

→

2-Nitro-5-phenoxytoluene

Disolventes

N,N-dimethylacetamide

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.STIRRINGthe mixture was stirred at 70°-80° C. for 30 minutes
2. 2
   Temperaturathe mixture was heated at 135°-140° C. for 2 hours
3. 3
   Temperaturaafter cooling
4. 4
   Concentraciónconcentrated in vacuo
5. 5
   workup.ADDITIONthe residue was introduced into ice
6. 6
   Filtraciónthe crystalline product was filtered off with suction
7. 7
   Lavadowashed with water
8. 8
   Otrodried

Procedimiento

14.1 g (150 mmol) of phenol were dissolved in 120 ml of anhydrous N,N-dimethylacetamide, while stirring, 20.6 g (150 mmol) of finely powdered potassium carbonate were added and the mixture was stirred at 70°-80° C. for 30 minutes. After cooling to 20° C., 23.25 g (18.3 ml, 150 mmol) of 5-fluoro-2-nitrotoluene were added dropwise, the mixture was heated at 135°-140° C. for 2 hours and, after cooling, concentrated in vacuo, the residue was introduced into ice and the crystalline product was filtered off with suction, washed with water and dried, 30 g, melting point 43°-46° C.

Fuente