Reacción #1838043

Ecuación de reacción

Thieno[3,2-d]pyrimidin-4(3H)-one

acetic acid

bromine

acetic acid

→

title compound

7-bromothieno[3,2-d]pyrimidin-4(3H)-one

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONwas slowly added to the solution
2. 2
   Otroprepared
3. 3
   TemperaturaThe reaction solution was cooled to room temperature
4. 4
   Otroacetic acid was removed by distillation under reduced pressure
5. 5
   workup.ADDITIONThe reaction mixture was poured into an ice water
6. 6
   Filtraciónthe resulting solid compound was filtered
7. 7
   Otrodried

Procedimiento

Thieno[3,2-d]pyrimidin-4(3H)-one (38.0 g, 0.25 mol) was dissolved in acetic acid (143 mL, 2.5 mol), and bromine (40.4 mL, 0.78 mol) diluted with acetic acid (122 mL, 2.1 mol) was slowly added to the solution prepared. The reaction solution was stirred in a sealed reactor for 18 hours at 120° C. The reaction solution was cooled to room temperature and acetic acid was removed by distillation under reduced pressure. The reaction mixture was poured into an ice water to generate a solid compound, and the resulting solid compound was filtered and dried. The title compound was obtained without purification (37.5 g, 65%).

Fuente