Reacción #1833211

Ecuación de reacción

2,6-dichloro-5-methoxy pyrimidine

vinyl magnesium bromide

2,3-dichloro-5,6-dicyano-p-benzoquinone

→

title compound

Rendimiento 60.0%

2,6-Dichloro-5-methoxy-4-vinyl pyrimidine

Rendimiento 60.0%

Disolventes

tetrahydrofuran

tetrahydrofuran

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroExcess Grignard reagent was quenched by addition of acetone (200 milliliters (mL)) while the temperature of the mixture
2. 2
   Temperaturawas maintained at a temperature below 20° C
3. 3
   workup.STIRRINGstirred overnight
4. 4
   OtroA yellow solid precipitated out
5. 5
   FiltraciónThe solid was filtered
6. 6
   Lavadowashed with ethyl acetate (500 mL)
7. 7
   ConcentraciónThe filtrate was concentrated under reduced pressure
8. 8
   workup.ADDITIONthe resulting crude compound was diluted with ethyl acetate (2 liters (L))
9. 9
   OtroThe resulting undissolved, dark, semi-solid was separated by filtration
10. 10
    ConcentraciónIt was further concentrated under reduced pressure
11. 11
    Otroto provide a crude compound, which
12. 12
    Otrowas purified by column chromatography
13. 13
    LavadoThe compound was eluted with 5% to 10% ethyl acetate in hexane mixture

Procedimiento

To a solution of commercially available 2,6-dichloro-5-methoxy pyrimidine (100 grams (g), 0.55 moles (mol)) in dry tetrahydrofuran was added, dropwise, 1 molar (M) vinyl magnesium bromide in tetrahydrofuran solvent (124 g, 0.94 mol) over one hour (h) at room temperature. The mixture was then stirred for 4 h at room temperature. Excess Grignard reagent was quenched by addition of acetone (200 milliliters (mL)) while the temperature of the mixture was maintained at a temperature below 20° C. Thereafter, 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ; 151 g, 0.67 mol) was added at once and stirred overnight. A yellow solid precipitated out. The solid was filtered and washed with ethyl acetate (500 mL). The filtrate was concentrated under reduced pressure and the resulting crude compound was diluted with ethyl acetate (2 liters (L)). The resulting undissolved, dark, semi-solid was separated by filtration using ethyl acetate. It was further concentrated under reduced pressure to provide a crude compound, which was purified by column chromatography. The compound was eluted with 5% to 10% ethyl acetate in hexane mixture to provide the title compound (70 g, 60%): mp 60-61° C.; 1H NMR (CDCl3) δ 3.99 (s, 3H), 5.85 (d, 1H), 6.75 (d, 1H), 6.95 (dd, 1H).

Fuente