Reacción #1824339

Ecuación de reacción

sodium hydroxide

1-Chloro-3,3-dimethylbutane

magnesium

iodine crystals

diethyl ether

→

4,4-dimethyl pentanoic acid

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONThe mixture was poured onto dry ice (50 g) very slowly
2. 2
   Otrothe basic aqueous layer provided
3. 3
   Extracciónextracted with diethyl ether (x2)
4. 4
   Extracciónextracted with diethyl ether which
5. 5
   Secadowas dried over magnesium sulphate
6. 6
   Filtraciónfiltered
7. 7
   Otrothen evaporated under vacuum

Procedimiento

1-Chloro-3,3-dimethylbutane (log) was added dropwise to magnesium turnings (2 g) with an initiating amount of iodine crystals in dry diethyl ether (100 ml) and Grignard formation allowed to proceed to completion over 1 hour. The mixture was poured onto dry ice (50 g) very slowly and 0.5 N sodium hydroxide added and the basic aqueous layer provided extracted with diethyl ether (x2). The basic aqueous layer was acidified and extracted with diethyl ether which was dried over magnesium sulphate, filtered then evaporated under vacuum to yield 7.2 g of 4,4-dimethyl pentanoic acid.

Fuente