Reacción #1824333

Ecuación de reacción

Sodium hydroxide

2-ethanoyloxy-3-(3,3-dimethylbutyl)-naphthalene-1,4-dione

→

title compound

Rendimiento 99.7%

2-(3.3-dimethylbutyl)-3-hydroxy-naphthalene-1.4-dione

Rendimiento 99.7%

Disolventes

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe THF was removed under vacuum
2. 2
   Lavadothe resultant solution was washed with diethyl ether (3x)
3. 3
   ExtracciónThe aqueous layer was acidified then extracted with diethyl ether (x3)
4. 4
   Lavadothe combined extracts washed with water
5. 5
   Secadodried over magnesium sulphate
6. 6
   Otrothen evaporated to dryness under vacuum

Procedimiento

Sodium hydroxide solution (1M; 100 ml) was added to a solution of 2-ethanoyloxy-3-(3,3-dimethylbutyl)-naphthalene-1,4-dione (3.5 g)(see Example 44) in THF (100 ml) at room temperature and stirred for 4 hours. The THF was removed under vacuum and the resultant solution was washed with diethyl ether (3x). The aqueous layer was acidified then extracted with diethyl ether (x3), the combined extracts washed with water, dried over magnesium sulphate then evaporated to dryness under vacuum to yield 3 g title compound.

Fuente