Reacción #1824326

Ecuación de reacción

product

2-(1,1-dimethylprop-2-enyl)-3-hydroxy-naphthalene-1.4-dione

methoxyamine hydrochloride

ether

→

title compound

2-(1,1-dimethylprop-2-enyl)-2-hydroxy-1-methoxyimino-naphthalene-4-one

Disolventes

pyridine

Condiciones de reacción

Tratamiento posterior

1. 1
   Lavadowashed with water (2×10 ml) , 2M hydrochloric acid (2×10 ml), water (2×10 ml), saturated sodium chloride solution (10 ml)
2. 2
   Secadodried over magnesium sulphate
3. 3
   FiltraciónFiltration and evaporation of the solvent under reduced pressure and silica gel chromatography

Procedimiento

A solution of the product of Example 1 (b) (250 mg, 1.03 mmol) and methoxyamine hydrochloride (95 mg, 1.14 mmol) in pyridine (5 ml) was stirred for 48 hours. The reaction mixture was dissolved in ether (50 ml) and washed with water (2×10 ml) , 2M hydrochloric acid (2×10 ml), water (2×10 ml), saturated sodium chloride solution (10 ml) and dried over magnesium sulphate. Filtration and evaporation of the solvent under reduced pressure and silica gel chromatography yielded the title compound (56 mg).

Fuente