Reacción #1824321

Ecuación de reacción

1-(2-ethylhexyl)-2-methylbenzimidazole

o-aminophenol

sulfur

→

2-(1-(2-Ethylhexy1)benzimidazol-2-yl)-benzoxazole

Disolventes

pyridine

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturaunder reflux for 18 hours
2. 2
   Otrothe crude product is precipitated by addition of water
3. 3
   Otrorecrystallization from n-hexane
4. 4
   workup.ADDITIONwith addition of active charcoal
5. 5
   Otrogives 5.7 g (16% of theory) of product, which

Procedimiento

24.4 g (0.1 mol) of 1-(2-ethylhexyl)-2-methylbenzimidazole (prepared by heating N-2-ethylhexyl-o-phenylenediamine in acetic acid/hydrochloric acid), 10.9 g (0.1 mol) of o-aminophenol and 9.6 g (0.3 mol) of sulfur in 100 ml of pyridine are heated under reflux for 18 hours. After cooling to room temperature, the crude product is precipitated by addition of water. Multiple recrystallization from n-hexane with addition of active charcoal gives 5.7 g (16% of theory) of product, which according to melting point, EPLC and UV determination is identical to the compound obtained in Example 7.

Fuente