Reacción #1824320

Ecuación de reacción

2,5-dithia cyclohexanone

cysteine decyl ester hydrochloride

triethyl amine

→

S-(2-mercaptoethyl)-N-(2-mercapto-1(decyloxycarbonyl)-ethyl)-mercaptoacetamide

Disolventes

dichloromethane

dichloromethane

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONare added
2. 2
   Lavadowashed three times with 2% aqueous citric acid, saturated sodium hydrogencarbonate solution
3. 3
   SecadoAfter drying above sodium sulfate
4. 4
   Otrothe solvent is evaporated under reduced pressure
5. 5
   OtroThe oily residue is crystallized by trituration with diethyl ether

Procedimiento

13.42 g (0.1 mol) of 2,5-dithia cyclohexanone dissolved in 250 ml of anhydrous dichloromethane are added by dropping, and in an argon atmosphere, to a solution of 29.79 g (0.1 mol) of cysteine decyl ester hydrochloride and 10.12 g (0.1 mol) of triethyl amine in 500 ml of anhydrous dichloromethane. The reaction mixture is kept agitated overnight at room temperature and then washed three times with 2% aqueous citric acid, saturated sodium hydrogencarbonate solution and with water. After drying above sodium sulfate, the solvent is evaporated under reduced pressure. The oily residue is crystallized by trituration with diethyl ether.

Fuente