Reacción #1824301

Ecuación de reacción

5-chloro-4-[2-(chloromethyl)phenyl]-2,4-dihydro-2-methyl-3H-1,2,4-triazol-3-one

1-[3,5-dichlorophenyl]ethanone oxime

1-[3-(trifluoromethyl)phenyl]ethanone oxime

→

5-chloro-2,4-dihydro-2-methyl-4-[2-[[[[1-[3(trifluoromethyl)phenyl]-ethylidene]amino]oxy]methyl]phenyl]-3H-1,2,4-triazol-3-one

Condiciones de reacción

Procedimiento

Preferred oximes of Formula IV for use in this process include 1-[3-(trifluoromethyl)phenyl]ethanone oxime, 1-[3,5-(bistrifluoromethyl)phenyl]ethanone oxime, and 1-[3,5-dichlorophenyl]ethanone oxime. Examples of the process of Step 2 include the reaction of 5-chloro-4-[2-(chloromethyl)phenyl]-2,4-dihydro-2-methyl-3H-1,2,4-triazol-3-one one with -1-[3,5-(bistrifluoromethyl)phenyl]ethanone oxime to form 5-chloro-2,4-dihydro-2-methyl-4-[2-[[[[1-[3(trifluoromethyl)phenyl]-ethylidene]amino]oxy]methyl]phenyl]-3H-1,2,4-triazol-3-one; the reaction of 5-chloro-4-[2-(chloromethyl)phenyl]-2,4-dihydro-2-methyl-3H-1,2,4-triazol-3-one with 1-[3,5-(bistrifluoromethyl)phenyl]ethanone oxime to form 5-chloro-2,4-dihydro-2-methyl-4-[2-[[[[1-[3(bistrifluoromethyl)phenyl]-ethylidene]amino]oxy]methyl]phenyl]-3H- 1,2,4-triazol-3-one.

Fuente