Reacción #1819430

Ecuación de reacción

sodium acetate trihydrate

2,3,6-trimethylaniline

acetic acid

chloroacetyl chloride

→

2-chloro-2',3',6'-trimethylacetanilide

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONwas added
2. 2
   workup.ADDITIONmixed quickly
3. 3
   Filtraciónthe solid material was filtered off
4. 4
   Lavadowashed carefully with water
5. 5
   OtroAfter drying
6. 6
   Otroa yield of 9.94 g (81%) was obtained

Procedimiento

A mixture of 7.8 g of 2,3,6-trimethylaniline R. A. Scherrer and H. R. Beatty, J. Org. Chem. 37, 1681 (1972), and 50 ml glacial acetic acid was cooled to 10° C. in a glass stoppered bottle, 7.23 g chloroacetyl chloride was added, mixed quickly and followed immediately by a cooled solution of 19.3 g sodium acetate trihydrate in 80 ml water. The mixture was shaked for 30 min. and the solid material was filtered off and washed carefully with water. After drying, a yield of 9.94 g (81%) was obtained. It melted at 145°-146° C.

Fuente