Reacción #1818819

Ecuación de reacción

1-oxo-2,3,9,10-tetrahydro-1H-benzo[b]indeno[5,4-f]thiepin-6-carboxylic acid

sodium hydroxide

sodium borohydride

→

(±)-1-Hydroxy-2,3,9,10-tetrahydro-1H-benzo[b]indeno-[5,4-f]thiepin-6-carboxylic acid

Disolventes

water

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.STIRRINGthe reaction mixture was stirred at room temperature overnight
2. 2
   OtroCareful acidification of the mixture with 10% hydrochloric acid precipitated the racemic title compound which
3. 3
   Filtraciónwas collected by filtration
4. 4
   Lavadowashed well with water

Procedimiento

A suspension of 1-oxo-2,3,9,10-tetrahydro-1H-benzo[b]indeno[5,4-f]thiepin-6-carboxylic acid (3.10 g, 10 mmole) in water (60 ml) was stirred during the addition of 1N sodium hydroxide solution (10 ml). After stirring for 15 minutes the mixture was treated with sodium borohydride (0.95 g, 25 mmole) in portions and the reaction mixture was stirred at room temperature overnight. Careful acidification of the mixture with 10% hydrochloric acid precipitated the racemic title compound which was collected by filtration and washed well with water.

Fuente