Reacción #1818377

ord-a7a774a5e6354ed58ee854c3ee76d7be

Ecuación de reacción

N=C(N)NCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)O
beta-guanidinopropionyl-L-histidine
O=S(=O)(O)O
H2SO4
NCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)O
βAla-His
CCSC(=N)N
S-ethylisothiourea
→
N[C@@H](Cc1c[nH]cn1)C(=O)O
histidine
N=C(N)NCCC(=O)O
beta-guanidinopropionic acid

Reactantes

N=C(N)NCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)O
beta-guanidinopropionyl-L-histidine
O=S(=O)(O)O
H2SO4
NCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)O
βAla-His
CCSC(=N)N
S-ethylisothiourea

Reactivos

Ninguno

Disolventes

O
H2O

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    Otroyield
  2. 2
    OtroHydrolysis

Procedimiento

To prepare beta-guanidinopropionyl-L-histidine.H2O, (n=2) S-ethylisothiourea.H2SO4 (5.0 g) and βAla-His (5.3 g) were reacted by the procedure described in Example 1: yield, 38.8%; mp, 121°-124° C., decomp. Hydrolysis as described in Example 1 gave beta-guanidinopropionic acid and histidine tlc.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US03995051uspto-grants-1976_11