Reacción #1812061

Ecuación de reacción

2-amino-4-chloronicotinaldehyde

2-acetyl-3-trifluoromethylpyridine

t-BuOK

→

desired product

5-Chloro-2-(3-(trifluoromethyl)pyridin-2-yl)-[1,8]naphthyridine

Disolventes

THF

Condiciones de reacción

Tratamiento posterior

1. 1
   ConcentraciónConcentrate the reaction mixture under vacuum
2. 2
   workup.ADDITIONdilute the residue with saturated aq. ammonium chloride (10 mL)
3. 3
   Filtraciónfilter the solid
4. 4
   Lavadowash the solid with water
5. 5
   Otrodry under high vacuum

Procedimiento

Dissolve 2-amino-4-chloronicotinaldehyde (78 mg, 0.5 mmol) and 2-acetyl-3-trifluoromethylpyridine (95 mg, 0.5 mmol) in anhydrous THF (2.0 mL) and cool it to −20° C. under N2 atmosphere. Add in portion t-BuOK (112 mg, 1.0 mmol) to the reaction mixture and stir the mixture at 10° C. for 2 hours. Concentrate the reaction mixture under vacuum, dilute the residue with saturated aq. ammonium chloride (10 mL), filter the solid, wash the solid with water and dry under high vacuum to afford desired product as a cream colored solid.

Fuente