Reacción #1798606

Ecuación de reacción

NaHSO3

5-nitroindazole

iodine

potassium hydroxide

→

title compound

Rendimiento 98.0%

3-Iodo-5-nitro-1H-indazole

Rendimiento 98.0%

Disolventes

DMF

Condiciones de reacción

Tratamiento posterior

1. 1
   Filtraciónfiltered
2. 2
   LavadoThe filtercake was washed with water
3. 3
   Otrodried in vacuo

Procedimiento

A solution of 5-nitroindazole (8.50 g, 52.13 mmol) in DMF was treated with iodine (26.46 g, 104.27 mmol) and potassium hydroxide pellets (11.70 g, 208.54 mmol) at room temperature, stirred for 4 days, poured into NaHSO3 solution (11.06 g in 200 mL water) and filtered. The filtercake was washed with water and dried in vacuo to provide the title compound as a yellow solid, 14.74 g (98% yield), characterized by NMR and mass spectral analyses.

Fuente