Reacción #1797493

Ecuación de reacción

5-aminoindane

acetic anhydride

→

5-(N-acetylamino)indane

Rendimiento 84.6%

Disolventes

—

ice water

acetic acid

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONAfter completion of the dropwise addition
2. 2
   OtroAfter completion of the reaction
3. 3
   Otrothe reaction liquid
4. 4
   workup.STIRRINGwhile stirring
5. 5
   OtroCrystals precipitated
6. 6
   Filtraciónwere filtered off
7. 7
   Lavadowashed with 1,000 ml of water
8. 8
   OtroThe crystals obtained
9. 9
   Otrowere dried

Procedimiento

33.3 g (0.25 mol) of 5-aminoindane (a product of Tokyo Chemical Industry Co. Ltd.) was dissolved in 250 ml of glacial acetic acid, the resulting solution was heated to 50° C., and 51.0 g (0.5 mol) of acetic anhydride was added dropwise thereto. After completion of the dropwise addition, the resulting solution was stirred for 4 hours. After completion of the reaction, the reaction liquid was poured in 1,500 ml of ice water while stirring. Crystals precipitated were filtered off, and washed with 1,000 ml of water. The crystals obtained were dried to obtain 37.06 g of 5-(N-acetylamino)indane (yield: 84.6%, melting point: 100.5 to 103.5° C.)

Fuente