Reacción #1792

Ecuación de reacción

sulfonylpyran-4-one

NaBH4

→

sulfonylpyran-4-ol

Disolventes

MeOH

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe solvent was removed under reduced pressure
2. 2
   Otrothe crude oil was chromatographed on a silica gel column
3. 3
   Lavadohexanes and eluted with same
4. 4
   Otrothe solvent was removed under reduced pressure

Procedimiento

A stirred solution of sulfonylpyran-4-one (1.2 g, 8.1 mmol) in MeOH (20 mL) was cooled to 0° C. under Argon and treated with NaBH4 (331 mg, 9.0 mmol). The reaction was stirred over 16 h and allowed to warm to ambient temperature. The solvent was removed under reduced pressure and the crude oil was chromatographed on a silica gel column packed in 50:50 EtOAc:hexanes and eluted with same. The appropriate fractions were combined and the solvent was removed under reduced pressure to give the sulfonylpyran-4-ol.

Fuente