Reacción #1785954

Ecuación de reacción

(R)-(−)-2-[3-[3-(1-tert-Butylcarbonylmethyl-2-oxo-5-c yclohexyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-3-yl)urei do]phenyl]-2-methylpropionic acid

N,N′-dibenzylethylenediamine

→

title compound

Rendimiento 89.3%

(R)-2-[3-[3-(1-tert-butylcarbonylmethyl-2-oxo-5-cyclohexyl-1,3,4,5-tetrahydro-2H-1,5-benzodi azepin-3-yl)ureido]phenyl]-2-methylpropionic acid N,N′-dibenzylethylenediamine salt

Rendimiento 89.3%

Disolventes

acetonitrile

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.DISSOLUTIONwere then dissolved
2. 2
   Temperaturaunder heat
3. 3
   OtroCrystals so precipitated
4. 4
   Filtraciónwere collected by filtration
5. 5
   Otrodried

Procedimiento

(R)-(−)-2-[3-[3-(1-tert-Butylcarbonylmethyl-2-oxo-5-c yclohexyl-1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-3-yl)urei do]phenyl]-2-methylpropionic acid (158 mg) and N,N′-dibenzylethylenediamine (67 mg) were added to acetonitrile (2 mL), and were then dissolved under heat. The reaction mixture was allowed to stand. Crystals so precipitated were collected by filtration and dried, whereby the title compound (200 mg) was obtained. Yield: 89%.

Fuente