Reacción #1771993

ord-40794a691015423f8f8e6dd4b847146a

Ecuación de reacción

CC(C)(C)OC(=O)N1CC(c2ccccc2)C[C@H]1C(=O)O
Boc-4-phenylproline
→
CC(C)(C)OC(=O)N1CC(C2CCCCC2)C[C@H]1C(=O)O
product
Rendimiento 95.4%
CC(C)(C)OC(=O)N1CC(C2CCCCC2)C[C@H]1C(=O)O
Boc-4-cyclohexylproline
Rendimiento 95.4%

Reactantes

CC(C)(C)OC(=O)N1CC(c2ccccc2)C[C@H]1C(=O)O
Boc-4-phenylproline

Reactivos

[Rh]
Rh on carbon

Disolventes

CO
methanol

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Tratamiento posterior

  1. 1
    FiltraciónThe mixture was filtered
  2. 2
    Concentraciónconcentrated

Procedimiento

A solution of the commercially available Boc-4-phenylproline (750 mg) and 5% Rh on carbon (750 mg) in methanol (15 mL) was hydrogenated at 50 psi for 24 hours. The mixture was filtered and concentrated to give 730 mg of product.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: USRE043298E1uspto-grants-2012_04