Reacción #1771991

Ecuación de reacción

Boc-Pro(4,4-diMe)-OH

thionylchloride

methanol

→

4,4-Dimethylproline Methylester Hydrochloride Salt

Condiciones de reacción

Tratamiento posterior

1. 1
   ConcentraciónThe reaction mixture was concentrated to an amorphous solid (377 mg, 95%)

Procedimiento

To a solution of Boc-Pro(4,4-diMe)-OH (0.5 g, 2.06 mmol) in anhydrous methanol (8 ml) was added dropwise thionylchloride (448 g, 6.18 mmol) and the reaction was stirred for six hours at room temperature. The reaction mixture was concentrated to an amorphous solid (377 mg, 95%).

Fuente