Reacción #1765251

Ecuación de reacción

Sodium methoxide

1-(6-chloro-pyridin-3-yl)-propan-1-one

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product

Rendimiento 77.0%

1-(6-Methoxy-pyridin-3-yl)-propan-1-one

Rendimiento 77.0%

Disolventes

methanol

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturathe reaction mixture was heated
2. 2
   Temperaturaunder reflux for eighteen hours
3. 3
   ConcentraciónThe solution was concentrated to fifty percent
4. 4
   workup.ADDITIONdiluted with water (100 mL)
5. 5
   Extracciónextracted with ethyl acetate (2×100 mL)
6. 6
   LavadoThe combined extracts were washed with brine
7. 7
   Secadodried (Na2SO4)
8. 8
   Concentraciónconcentrated

Procedimiento

Sodium methoxide (2.8 g, 50 mmol) was added to a solution of 1-(6-chloro-pyridin-3-yl)-propan-1-one (2.8 g, 16.5 mmol) in methanol (70 mL) and the reaction mixture was heated under reflux for eighteen hours. The solution was concentrated to fifty percent, diluted with water (100 mL) and extracted with ethyl acetate (2×100 mL). The combined extracts were washed with brine, dried (Na2SO4) and concentrated to give product as a colorless oil (2.1 g, 77 percent yield), which was used without further purification.

Fuente