Reacción #1755461

Ecuación de reacción

2-methyl-propane-2-sulfinic acid [2-(3,5-dimethyl-phenyl)-1-(1-methyl-1H-pyrazol-4-yl)-ethyl]-amide

hydrogenchloride

→

2-(3,5-Dimethyl-phenyl)-1-(1-methyl-1H-pyrazol-4-yl)-ethylamine

Rendimiento 77.0%

Disolventes

methanol

dioxane

Condiciones de reacción

Tratamiento posterior

1. 1
   OtroThe reaction mixture was quenched with aqueous potassium carbonate solution
2. 2
   Extracciónextracted
3. 3
   Secadothe organic phases dried over magnesium sulfate
4. 4
   OtroAfter evaporation of the solvent a yellowish oil
5. 5
   Otrowas obtained in 77% yield (1.05 g)

Procedimiento

A solution of RS 2-methyl-propane-2-sulfinic acid [2-(3,5-dimethyl-phenyl)-1-(1-methyl-1H-pyrazol-4-yl)-ethyl]-amide (2.0 g) in methanol (12 ml) was treated with a solution of hydrogenchloride in dioxane (12 ml, 4 N) at room temperature overnight. The reaction mixture was quenched with aqueous potassium carbonate solution and adjusted to pH 8-9, extracted and the organic phases dried over magnesium sulfate. After evaporation of the solvent a yellowish oil was obtained in 77% yield (1.05 g).

Fuente