Reacción #1755

Ecuación de reacción

water

trans-O-acetyl-4-(4-chloromethylphenyl)-cyclohexanol

potassium carbonate

diethylamine

→

trans-O-Acetyl-4-(4-diethylaminomethylphenyl)-cyclohexanol

Disolventes

dimethylformamide

Condiciones de reacción

Tratamiento posterior

1. 1
   Extracciónthe mixture is extracted with methylene chloride
2. 2
   OtroThe organic phase is dried
3. 3
   Otroevaporated down in vacuo
4. 4
   Otrothe residue remaining is purified by column chromatography (aluminium oxide basic, activity stage III, ICN; petroleum ether/ethyl acetate=15:1)

Procedimiento

A solution of 1 g (3.75 mmol) of trans-O-acetyl-4-(4-chloromethylphenyl)-cyclohexanol in 10 ml of dimethylformamide is mixed with 0.52 g (3.75 mmol) of potassium carbonate and 0.27 g (3.75 mmol) of diethylamine. This mixture is heated to 50° C. for 6 hours with stirring, then water is added and the mixture is extracted with methylene chloride. The organic phase is dried, evaporated down in vacuo and the residue remaining is purified by column chromatography (aluminium oxide basic, activity stage III, ICN; petroleum ether/ethyl acetate=15:1). Colourless oil.

Fuente