Reacción #1753389

ord-85f9e56b455b434daf199a45d64eedf2

Ecuación de reacción

CNCC(=O)OC.Cl
N-methylglycine methyl ester hydrochloride
On1nnc2ccccc21
HOBt
CCN=C=NCCCN(C)C
WSC
CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)O
N-(tert-Butoxycarbonyl)-phenylalanine
→
COC(=O)CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C
Methyl N-(tert-butoxycarbonyl)-phenylalanyl-N-methylglycinate

Reactantes

CNCC(=O)OC.Cl
N-methylglycine methyl ester hydrochloride
On1nnc2ccccc21
HOBt
CCN=C=NCCCN(C)C
WSC
CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)O
N-(tert-Butoxycarbonyl)-phenylalanine

Reactivos

Ninguno

Disolventes

CN(C)C=O
DMF
CCN(CC)CC
triethylamine

Condiciones de reacción

Condiciones detalladas
See reaction.notes.procedure_details.

Procedimiento

N-(tert-Butoxycarbonyl)-phenylalanine (4.85 g, 15 mmol) was condensed with N-methylglycine methyl ester hydrochloride in DMF in the presence of triethylamine, HOBt and WSC.

Fuente

DOI: 10.6084/m9.figshare.5104873.v1Patente: US08044056B2uspto-grants-2011_10