Reacción #1747136

Ecuación de reacción

3-o-methoxyphenoxypyrrolidine

4-chloro-2-phenylquinazoline

→

4-[3-(2-Methoxyphenoxy)-1-pyrrolidinyl]-2-phenylquinazoline

Disolventes

isopropanol

Condiciones de reacción

Tratamiento posterior

1. 1
   workup.ADDITIONwas added
2. 2
   Temperaturathe mixture refluxed for 15 min
3. 3
   Otrosubsided to room temperature
4. 4
   Otroafter standing at room temperature for 11
5. 5
   Otro2 hr
6. 6
   Otrothe resulting reaction mixture
7. 7
   Filtraciónwas filtered
8. 8
   OtroThe crystalline solid was recrystallized with isopropanol

Procedimiento

To a solution containing 150 ml of isopropanol and 4.8 g (0.025 mole) of 3-o-methoxyphenoxypyrrolidine was added, with stirring, 6.15 g (0.025 mole) of 4-chloro-2-phenylquinazoline. The reaction was exothermic and the mixture refluxed for 15 min. The temperature subsided to room temperature and, after standing at room temperature for 11/2 hr, the resulting reaction mixture was filtered. The crystalline solid was recrystallized with isopropanol. Yield of product was 1.9 g, m.p. 142°-144° C.

Fuente