Reacción #1747132

Ecuación de reacción

2-phenyl-4-chloroquinazoline

4-hydroxypiperidine

sodium hydroxide

→

title compound

Rendimiento 41.9%

1-(2-Phenyl-4-quinazolinyl)-4-piperidinol

Rendimiento 41.9%

Disolventes

ethyl alcohol

Condiciones de reacción

Tratamiento posterior

1. 1
   Temperaturawas refluxed for 3 hrs
2. 2
   Temperaturathe mixture was refluxed for an additional 2 hr period
3. 3
   FiltraciónThe mixture was filtered
4. 4
   workup.ADDITIONthe filtrate was added to 300 ml of water
5. 5
   OtroThe white crystalline precipitate was separated
6. 6
   Otrorecrystallized with methanol and water

Procedimiento

A mixture containing 6 g (0.025 mole) of 2-phenyl-4-chloroquinazoline, 3,53 g (0.035 mole) of 4-hydroxypiperidine and 100 ml of 95% ethyl alcohol was refluxed for 3 hrs. One gram of sodium hydroxide (in one ml of water) was added and the mixture was refluxed for an additional 2 hr period. The mixture was filtered and the filtrate was added to 300 ml of water. The white crystalline precipitate was separated and recrystallized with methanol and water to give 3.2 g of the title compound, m.p. 165°-167° C.

Fuente