Reacción #1736786

Ecuación de reacción

4-(2-piperidinoethoxy)-benzoic acid, hydrochloride

6-benzoyloxy-2-(4-benzoyloxyphenyl)-benzo[b]thiophene

→

desired product

6-benzoyloxy-2-(4-benzoyloxyphenyl)-3-[4-(2-piperidinoethoxy)benzoyl]benzo[b]thiophene, hydrochloride

Condiciones de reacción

Tratamiento posterior

1. 1
   Otroformed from 18.9 g

Procedimiento

The process of this example was run as was the process of Example 1, starting with the acid chloride formed from 18.9 g. of 4-(2-piperidinoethoxy)-benzoic acid, hydrochloride, and 20 g. of 6-benzoyloxy-2-(4-benzoyloxyphenyl)-benzo[b]thiophene. The reaction mixture was stirred for 1.5 hours, and was then worked up as described in Example 1 to obtain the desired product as an oil. A small portion of the crude product was crystallized from denatured ethanol to provide an analytical sample, m.p. 230°-233° C., the identity of which was confirmed by nmr analysis.

Fuente